Does Subsequent Pregnancy Influence Breast Cancer Survival
Annual rept. 15 Sep 97-14 Sep 98
SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
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In 1998 approximately 36,000 women less than age 45 will be diagnosed with breast cancer. For these young patients therapeutic options are a major concern. Many have delayed childbearing. Their desire to start a family or have additional children has been found to impact their treatment decisions. Many doctors have been cautious in recommending pregnancy after breast cancer because of the recognized poor outcome of women diagnosed with breast cancer during pregnancy. Current therapeutic modalities are less toxic, of shorter duration and improve prognosis therefore, many pre-menopausal women remain fertile or regain fertility after primary breast cancer treatment. Recommendations concerning subsequent childbearing may significantly affect the quality of life for these young patients. However, the safety of subsequent pregnancy remains to be confirmed. Several population- based studies which relied on national registries have indicated pregnancy after treatment for breast cancer may enhance survival however, the authors have suggested that disease free women may be more likely to consider post-treatment childbearing. The current retrospective study conducted through review of Kaiser Permanente medical records will compare survival of women with a positive subsequent pregnancy history with matched cases with a negative post treatment pregnancy history. The ratio of matching is four to one providing adequate power to detect a hazard ratio of two or greater.
- Anatomy and Physiology
- Medicine and Medical Research