Progression and Metastasis of Mammary Carcinomas: Potential Role of the Muc1 Glycoprotein
Annual rept. 1 Aug 94-1 Sep 98
MAYO FOUNDATION ROCHESTER MN
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The carcinoma associated mucin, MUC1, is a large transmembrane glycoprotein that over-expressed on 92 of primary and metastatic breast cancers. We created a mouse that lacks a functional Muc-1 gene and demonstrated that mice developed normally. Mtag transgenic mice were bred onto the Muc-1 deficient and wild type backgrounds and tumor growth rates were compared. Mtag induced tumors grew significantly slower in Muc-1 deficient mice than in control mice. There were no differences in the rates of cellular proliferation or apoptosis in Mtag induced mammary tumors growing in Muc-1 deficient mice verses control mice. Depletion of NK cells resulted in acceleration of tumor growth rate in Muc-1 deficient animals but overall there were no consistent differences in tumor growth rate between Muc-1 deficient and wild type mice, irrespective of NK status. We demonstrated that mammary tumors induced by over-expression of the neu proto-oncogene in transgenic mice developed significantly faster in pure strain FVB mice than in Fl mice, suggesting that C57B16 mice may contain tumor suppresser genes that inhibit tumor development.
- Anatomy and Physiology
- Medicine and Medical Research