Accession Number:

ADA360956

Title:

Progression and Metastasis of Mammary Carcinomas: Potential Role of the Muc1 Glycoprotein

Descriptive Note:

Annual rept. 1 Aug 94-1 Sep 98

Corporate Author:

MAYO FOUNDATION ROCHESTER MN

Personal Author(s):

Report Date:

1998-09-01

Pagination or Media Count:

53.0

Abstract:

The carcinoma associated mucin, MUC1, is a large transmembrane glycoprotein that over-expressed on 92 of primary and metastatic breast cancers. We created a mouse that lacks a functional Muc-1 gene and demonstrated that mice developed normally. Mtag transgenic mice were bred onto the Muc-1 deficient and wild type backgrounds and tumor growth rates were compared. Mtag induced tumors grew significantly slower in Muc-1 deficient mice than in control mice. There were no differences in the rates of cellular proliferation or apoptosis in Mtag induced mammary tumors growing in Muc-1 deficient mice verses control mice. Depletion of NK cells resulted in acceleration of tumor growth rate in Muc-1 deficient animals but overall there were no consistent differences in tumor growth rate between Muc-1 deficient and wild type mice, irrespective of NK status. We demonstrated that mammary tumors induced by over-expression of the neu proto-oncogene in transgenic mice developed significantly faster in pure strain FVB mice than in Fl mice, suggesting that C57B16 mice may contain tumor suppresser genes that inhibit tumor development.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE