Novel Biopolymers Based on an Expanded Genetic Alphabet
Final rept. 5 Feb 98-5 Jan 99
FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY
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Problems encountered by the Navy can frequently be solved if only a specific receptor or catalyst could be discovered or developed for a particular ligand or a receptor. In these cases, the principal obstacle to solving the problem is often the unavailability of the receptor or catalyst in Nature, and the limits of chemical theory that prevent design. The equipment purchased under this grant was used to develop a method that promises to offer the Navy receptors and catalysts on demand, using a technology known as in vitro selection build on an expanded genetic information system, whose chemistry and enzymology was developed in the Benner laboratories over the past few years.