Accession Number:

ADA359960

Title:

The Effect of 2,3,4-Trimethylpentane on the Ultrastructure of Proximal Tubular Cells in Primary Cell Culture.

Descriptive Note:

Technical rept.

Corporate Author:

ARMSTRONG LAB WRIGHT-PATTERSON AFB OH

Report Date:

1989-08-01

Pagination or Media Count:

3.0

Abstract:

To aid in the assessment of the risk of Air Force personnel working with hydrocarbon fuels and compounds, an attempt was made to further characterize the nephropathy that results from exposure to hydrocarbons. The purpose of this study was to isolate and establish purified primary cultures of male rat proximal tubular cells suitable for experimental exposure to sublethal concentrations of 2,3,4-trimethylpentane TMP, a model hydrocarbon. Experiments were conducted to evaluated the cytotoxicity and metabolism of solubilized TMP in media containing or lacking the protein albumin.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE