Accession Number:

ADA359886

Title:

Biotherapy of Breast Cancer With EGF-Genistein.

Descriptive Note:

Annual rept. 16 Sep 97-15 Sep 98

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS

Personal Author(s):

Report Date:

1998-10-01

Pagination or Media Count:

78.0

Abstract:

Our proposed research plan involves laboratory studies using an in vivo severe combined immunodeficiency SCID mouse model of human metastatic breast cancer as well as cynomologous monkeys to examine the anti-breast cancer activity, toxicity, and pharmacodynamic features of EGF-Gen. Our primary goal in the proposed animal studies is to determine whether systemic exposure levels of EGF-Gen found to be therapeutically effective in SCD mouse models of human breast cancer can be achieved in cynomologous monkeys without excessive toxicity. The knowledge gained from these studies is expected to facilitate the design of effective biotherapy and combined biochemotherapy regimes for breast cancer patients. The proposed research is directly relevant to a critical issue in the treatment of breast cancer.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE