Control of Cell Migration during Development
Final rept. 1 Aug 96-31 Jul 98
CALIFORNIA UNIV BERKELEY
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Cell migrations are critical for normal development. For example, much of the human nervous system is generated by cell migration. Also, the spread of cancerous cells is a similar process. Few proteins that guide migrating cells have been identified. To identify additional proteins required for cell migration, we performed two genetic screens for Caenorhabditis Elegans mutants with displaced migratory cells. In these screens we identified 14 genes required for normal cell migration. We have cloned two of these genes, cam-1 and unc-34. Cam-1 encodes a receptor tyrosine kinase of the Ror class. Vertebrate Rors are expressed in the nervous system during development, but their function in development is not known.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research