Lifetime Alcohol Exposure and Breast Cancer Risk
Annual rept. 15 Sep 97-14 Sep 98
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
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This case-control study examines breast cancer risk in relation to lifetime alcohol consumption. Subjects are 1,350 pre-and post-menopausal women, age 35-79, from Erie and Niagara counties in New York State, with incident, pathologically confirmed breast cancer. Most controls have been interviewed as part of another study that has just ended. A small number of additional controls will be interviewed in the next years of this study to control for secular trends. Controls are randomly selected and frequency matched to cases on age, race and county of residence. Subjects receive a computerized interview that focuses on in-depth lifetime alcohol consumption history. Potential confounding factors are also assessed. A specimen bank is used to store biological samples for future research of serum and urinary markers of hormones, hormone metabolites, vitamins, genetic polyrnorphisms and blood levels of antioxidants and oxidative stress. This study provides an important opportunity for an efficient examination of alcohol and other risk factors, particularly genetic variability, in relation to breast cancer risk, with potential for clarification of a significant pub tic health problem. Since the inception of the study, 264 breast cancer cases and 1,816 controls have been interviewed and blood samples stored for 228 cases and 1,683 controls.
- Medicine and Medical Research