Her-2/Neu and Breast Cancer.
OREGON HEALTH SCIENCES UNIV PORTLAND
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The HER-2neu proto-oncogene is developmentally expressed as a 185 kDa trans-membrane tyrosine Idnase. Overexpression of HER-2 occurs in up to 30 of human adenocarcinornas and has been most extensively studied in breast and ovarian cancers, where it predicts poor prognosis for survival of the patient. Although HER-2 gene amplification is a common mechanism for overexpression, many human tumors and cell lines display HER-2 mRNA and protein overexpression in excess of the level accountable by gene copy number, or in absence of gene amplification.
- Medicine and Medical Research