The Role of Cyclin D1 Overexpression in Breast Cancer Progression
Final rept. 15 Jul 94-14 Jul 98
COLUMBIA UNIV NEW YORK
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The studies performed under this grant indicate that abnormalities in the expression of the cell cycle control proteins cyclin Dl, cyclin E and p27KiPI frequently occur during the development of breast cancer. They also revealed for the first time the existence of homeostatic feedback control mechanisms between these critical regulators of the cell cycle. These mechanisms may explain the paradoxical increase in expression of the p27KiPl protein in some breast cancer cells. These studies also revealed that increased expression of cyclin Dl or cyclin E can have complex phenotypic effects on cell proliferation, apoptosis and responses to TGF beta. Our studies on p27KiPl suggest that therapeutic strategies that further increase the level of expression of this protein, or mimic its activity, might provide a novel approach to breast cancer chemoprevention and therapy.
- Medicine and Medical Research