Magnetic Resonance-Guided Interstitial Laser Photocoagulation for the Treatment of Breast Cancer
Annual rept. 1 Aug 97-31 Jul 98
ARKANSAS UNIV AT LITTLE ROCK
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This study assesses magnetic resonance MR-guided interstitial laser photocoagulation ILP for the treatment of breast cancer. ILP has been successfully used for the treatment of a variety of solid tumors, and recent studies have indicated the capability of ILP, which employs low level heat 50 deg C for about 10 minutes, to kill breast cancer tissue. As breast cancer cells are often interspersed with surrounding normal tissue, making boundaries difficult to define by most diagnostic imaging methods, MR imaging is used to define tumor margins and extent. Our research group has developed a high-contrast, high-resolution method for MR imaging of the breast, called RODEO Rotating Delivery of Excitation Off-resonance, proven to have twice the sensitivity and specificity of mammography. Cellular death induced by ILP produces a phase change that can be visualized on MR images. This MRI hypointense zone can then be used to determine the adequacy of ILP treatment. The combination of RODEO imaging and a system for MRI-directed stereotaxic biopsy allows the accurate localization and placement of the laser fibers for ILP. This study tests the feasibility and outcome of MR-directed ILP in 30 patients with breast cancer who are scheduled for surgical removal of the lesion mastectomy or lumpectomy. Our major findings to date are 1 RODEO MRI can accurately identify cancers for laser ablation 2 Stereotaxic MRI needle positioning can be performed 3 Fast RODEO MR can accurately depict zones of ablation for interactive lip 4 ILP is an effective method for the minimally invasive ablation of breast cancer 5 MRI-guided ILP is safe and is a potential alternative to surgical lumpectomy and 6 MRI-guided ILP may have lower costs and provide better cosmesis than surgical lumpectomy.
- Medicine and Medical Research
- Nuclear Physics and Elementary Particle Physics