Accession Number:

ADA359100

Title:

Simulation of Protein Structure, Dynamics and Function in Organic Media.

Descriptive Note:

Final rept. 1 May 95-30 Jul 98

Corporate Author:

WASHINGTON UNIV SEATTLE DEPT OF MEDICINAL CHEMISTRY

Personal Author(s):

Report Date:

1998-07-01

Pagination or Media Count:

4.0

Abstract:

The overall goal of our ONR-sponsored research is to pursue realistic molecular modeling strudies pertinnent to the related properties of protein stability, dynamics, structure, function, and folding in aqueous solution. We have developed mixed solvent systems to investigate the conformational behavior of peptides and proteins in response to a change in environment. We have also been studying hydrophobic hydration and how it may affect the diffusivity of molecules and how it may be harnassed in the design of biomaterials.

Subject Categories:

  • Physical Chemistry
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE