Accession Number:

ADA359058

Title:

Treatment of Experimental Acute Radiation Disease in Mice with Probiotics, Quinolones, and General Gnotobiological Isolation

Descriptive Note:

Contract rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1998-09-01

Pagination or Media Count:

41.0

Abstract:

The effect of ciprofloxacin, lomefloxacin, amikacin, and probiotics Lactobacillus acidophilus 54, Bifidobacterium longum 44 on intestinal microflora, translocation, and mortality was studied in mice treated with 7.0 Gy radiation. Lactobacilli and bifidobacteria, selected by in vitro and in vivo methods, increased survival parameters of the mice. The effect of lactobacilli was higher under gnotobiological isolation. Lactobacilli suppressed the gram-negative enterics and decreased translocation of the strict anaerobes, but not streptococci. Lomefloxacin increased survival, reducing the intestinal counts and translocation of gram-negative enterics, but not streptococci. A lomefloxacinlactobacilli combination showed effects similar to lomefloxacin alone.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE