Accession Number:

ADA358078

Title:

Cell Growth Arrest Mediated by STAT Proteins in Breast Cancer Cells

Descriptive Note:

Annual rept. 1 Jul 1997-30 Jun 1998

Corporate Author:

YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1998-07-01

Pagination or Media Count:

37.0

Abstract:

Many growth factors, including epidermal growth factor EGF, can activate the signal transducer and activator of transcription STAT signaling pathway. Here, we demonstrate that STAT activation by EGF treatment is conditional EGF activates STAT1 and STAT3 in A431 but not in HeLa and PCl2 cells. Using a reconstituted in vitro STAT activation system, we have identified and partially purified a potential inhibitor s that is membrane associated and can block STAT activation induced by EGF in vitro. However, this inhibitor has no effect on STAT complexes after they are formed. We have further shown that this inhibitors also exists in many other cancer cell lines, suggesting that blocking the STAT activation during EGF signal transduction may play a significant role in the development of many kinds of cancers.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE