Mammary Gland Ontegeny and Neoplasia in Oxytocin Deficient Mice.
Annual rept. 1 Jul 97-30 Jun 98
PITTSBURGH UNIV PA
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The studies utilize oxytocin knock-out and wild type mice homozygous for the oxytocin gene to test the hypothesis that diminished oxytocin and the absence of its effect upon the mammary gland, may in part predispose the breast to neoplastic change and its corollary that exposure to oxytocin may be protective. The technical objectives of this proposal as follows. 1 Determine the prevalence of mammary neoplasia in the progeny of MMTV-infected mice that are bred with OT KO versus WT mice, 2 Determine if there are differences in the susceptibility of MMTV- infected KO versus MMTV-infected WT mice to develop mammary neoplasia when exposed in vivo to ovarian steroid hormones. If oxytocin is shown to be an important factor in breast cancer, exogenous oxytocin may be a potential safe, non-toxic measure in its prevention.
- Medicine and Medical Research