Fluorescence Lifetime Imaging for Breast Cancer Detection and Diagnosis
Annual rept. 1 Jul 97-30 Jun 98
PURDUE RESEARCH FOUNDATION LAFAYETTE IN
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In this exploratory research program, the use of fluorescent contrast agents for detection and diagnosis of sub-surface diseased tissues is demonstrated. Using Newton-Raphson inversion techniques, we demonstrated the ability to map fluorescence lifetime and quantum efficiency from frequency-domain measurements of photon migration using synthetic data sets. Multi-pixel instrumentation for generation of actual data sets was constructed and is planned to validate the approach of fluorescence lifetime imaging of breast disease using optical contrast agents.
- Medicine and Medical Research