Use of Biomarkers to Optimize Heat Acclimation in Women.
Final rept. 25 Sep 95-24 Sep 98
IOWA UNIV IOWA CITY
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These were designed to determine a if short-term estradiol supplementation ES improves heat dissipation and if HSP70 can serve as a biomarker to assess this improvement and b if ES for 7 days of heat exposure enhances the process of heat acclimation HA. We also determined if HSP70 measurements could predict the rate of HA. Results showed that ES in premenopausal women during the follicular phase of the menstrual cycle a did not enhance sweating, cutaneous blood flow, or the time required to achieve HA. Moreover, neither ES nor HA alone induced the synthesis of HSP70. These studies were designed to determine if ES would enhance exercise performance in the heat and what combination of ES and exercise training would enhance the acclimation of female ovariectomized rats to the heat. These studies showed that a ES had no effect on heat transfer to the skin or heat dissipation by evaporative cooling, but that ES increased thermotolerance in ovariectomized rats exercising at high ambient temperatures and b the combination of exertional heat exposure and ES, when compared to ES alone, enhances thermotolerance in rats exercising at a high ambient temperature.
- Medicine and Medical Research
- Stress Physiology