Accession Number:

ADA355452

Title:

Hemoglobin-Based Oxygen-Carrying Resuscitation Fluids.

Descriptive Note:

Corporate Author:

JEFFERSON MEDICAL COLL PHILADELPHIA PA

Personal Author(s):

• Reuven, Rabinovici
• Alan, Rudolph S.
• Lewis, Neville F.
• Giora, Feuerstein

Report Date:

1994-01-01

Pagination or Media Count:

8.0

Abstract:

Currently, transfusion of donor blood is the conventional treatment for profound hemorrhagic shock ATLS. However, very significant problems are inherent in human blood transfusions. First, there is an increasing shortage of donors which becomes more severe due to the rising incidence of AIDS carriers in blood- donating populations 5. Second, red blood cells carry multiple antigenic determinants so that donor blood must be carefully typed and cross-matched before administration, a time-consuming and mostly process. Third, blood has a limited shelf-life due to short storage viability, which at the present does not exceed one month. Fourth, blood storage and distribution is logistically- demanding because it must be stored and delivered at 40C. Finally, blood can carry virally-transmitted diseases such as AIDS and hepatitis. Therefore, there is a profound clinical, economical and logistical demand for a non-antigenic, disease-free, easily transportable and long-term storable blood substitute.

Descriptors:

• *HEPATITIS
• *ACQUIRED IMMUNE DEFICIENCY SYNDROME
• *HEMORRHAGIC SHOCK
• *BLOOD TRANSFUSION
• *BLOOD STORAGE
• *DONORS(MEDICINE)
• HUMANS
• POPULATION
• SHORT RANGE(TIME)
• VIABILITY
• STORAGE
• ERYTHROCYTES
• SHORTAGES
• SHELF LIFE
• ANTIGEN ANTIBODY REACTIONS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE