Accession Number:

ADA350927

Title:

New Rhenium Radiopharmaceuticals for the Selective Imaging and Therapy of Breast Cancer

Descriptive Note:

Annual rept. 12 May 97-11 May 98

Corporate Author:

NEW MEXICO STATE UNIV LAS CRUCES

Personal Author(s):

Report Date:

1998-06-01

Pagination or Media Count:

12.0

Abstract:

This report describes progress achieved during year-i of a three year project, which seeks to develop new technology to produce rhenium radiopharmaceuticals for the diagnostic imaging and therapy of breast cancer. The discovery of a new palladium catalyzed synthetic routes to alkynl and alkenyl-linked estradiol hydrazine derivatives has been a major advance. This reaction forms a new carbon-carbon bond between ethynyl or vinyl estradiol derivatives and N-acyl-4- iodophenylhydrazine, incorporating the hydrazine group in excellent yields without side reactions or degradation of the steroid. The reaction was used to prepare analogs attached to a polymeric support.

Subject Categories:

  • Pharmacology
  • Organic Chemistry
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE