The Effects of Melatonin on Menstrual Characteristics, Prolactin and Premenstrual Syndrome-Like Symptoms During a Simulated Eastward Deployment
ARMY AEROMEDICAL RESEARCH LAB FORT RUCKER AL
Pagination or Media Count:
In a previous study, we investigated the effect of exogenous melatonin 10 mg given at bedtime 2300 for 7 consecutive days during the late follicular and early luteal phase of the monthly cycle, on menstrual characteristics. Our results showed that under our specific conditions, exogenous melatonin has little effect on menstrual characteristics. Since melatonin receptors likely up-and down-regulate depending on the availability of melatonin, 2300 would be during the nightly endogenous increase and receptors should be at a low level. The study reported here was double blind and placebo controlled and was undertaken to determine whether exogenous melatonin 10 mg, given earlier in the day when melatonin receptors are at a high level 1300, would have a greater effect on menstrual characteristics. This study also involved the use of bright lights to shift activity rhythms and simulate an eastward deployment across six time zones.
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