Prevalence of Prognostic Biomarkers in Archival Specimens and Breast Cancer Survival Among White, Black, and Asian Women.
Final rept. 1 Sep 94-31 May 98,
KAISER FOUNDATION RESEARCH INST OAKLANDCA
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We assessed distributions of breast cancer tumor characteristics and molecular prognostic biomarkers by raceethnicity and socioeconomic position among paraffin-embedded tumor biopsy specimens from 135 U.S. women 48 white, 44 black, 43 Asian diagnosed with breast cancer between 1966 and 1990. No racialethnic or socio-economic differences in distributions were observed for tumor stage, lymph node involvement, estrogen, progesterone, and epidermal growth factor receptors, oncogenes Her2neu and p53, cytoplasmic proteins cathepsin-D and ps2, and two indices of cell growth, Ki67 and DNA ploidy, adjusting for age at diagnosis, menopausal status, place of birth and, for racialethnic comparisons, socioeconomic position. Black and Asian women, however, were 3.5 times 95 confidence interval CI 1.2-10.1 and 3.7 times 95 CI 1.3-10.6 more likely than white women to have a tumor size of more than 20 mm, and Asian women were 3.4 times 95 CI 1.1-10.4 more likely than black women to be positive for androgen receptor, adjusting for these same factors. No differences in distributions by socioeconomic position were observed for these latter two tumor characteristics. These data suggest that racialethnic and socioeconomic disparities in breast cancer survival are unlikely to be explained by differential distributions of molecular breast cancer prognostic biomarkers.
- Medicine and Medical Research