Accession Number:

ADA350278

Title:

New Approaches to the Labeling of Estrogens Useful for PET (Predoctral Training Program).

Descriptive Note:

Final rept.,

Corporate Author:

WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1998-06-01

Pagination or Media Count:

68.0

Abstract:

By incorporating a positron-emitting radionuclide into an estrogen receptor ligand, estrogen receptor-positive breast cancer can be visualized with Positron Emission Tomography PET. in the search for improved estrogen receptor imaging agents, three isomers of 16-methoxyestradiol were synthesized via two synthetic routes, each utilizing methyl hypofluorite. The unusual chemistry of methyl hypofluorite provides a previously unexplored route for functionalizing the 16-position of estradiol and would provide a means of rapidly incorporating carbon-11 into biomolecules. The estrogen receptor binding affinities for these isomers determined these compounds to be ineffective imaging agents for the estrogen receptor.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE