Accession Number:

ADA346908

Title:

Agricultural Use of Burkholderia (Pseudomonas) Cepacia: A Threat to Human Health?

Descriptive Note:

Corporate Author:

HAMMERSMITH HOSPITAL LONDON (UNITED KINGDOM)

Report Date:

1998-06-01

Pagination or Media Count:

8.0

Abstract:

In the past 2 decades, Burkholderia cepacia has emerged as a human pathogen causing numerous outbreaks, particularly among cystic fibrosis CF patients. One highly transmissible strain has spread across North America and Britain, and another between hospitalized CF and non-CF patients. Meanwhile, the organism has been developed as a biopesticide for protecting crops against fungal diseases and has potential as a bioremediation agent for breaking down recalcitrant herbicides and pesticides. However, B. cepacia is inherently resistant to multiple antibiotics selection of strains safe for environmental application is not at present possible phenotypically or genotypically molecular epidemiology and phylogenetic studies demonstrate that highly transmissible strains emerge randomly and the organism has a capacity for rapid mutation and adaptation facilitated by numerous insertion sequences, and a large, complex genome divided into separate chromosomes. Therefore, the widespread agricultural use of B. cepacia should be approached with caution.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE