Environmental Exposures, Genetic Polymorphisms and p53 Mutational Spectra in a Case-Control Study of Breast Cancer.
Annual rept. 1 Jan 95-31 Dec 96,
NATIONAL INSTITUTES OF HEALTH BETHESDA MD
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The first goal of this project is to determine the frequency of genetic polymorphisms for carcinogen metabolism and the p53 mutational spectra in a previously conducted breast cancer case-control study. We have determined that the NAT2 slow acetylator genotype and cigarette smoking is a risk factor for postmenopausal Caucasion women. Analyses for NAT1 is now in progress. We also have found that the alcohol dehydrogenase gene increases alcohol-related breast cancer risk. The sequencing for the p53 mutational spectra is in progress. To corroborate the epidemiological data, over 30 breast cell strains have been established and metabolism is being studied in relation to genotypes. Finally, to identify smoking related risk, we have been studying smoking behavior and addiction. Thus far, genetic polymorphisms in the dopamine transporter and dopamine receptors have been associated with smoking. For the latter, in African Americans, the data indicates that the genetic polymorphism might predict the success of smoking cessation therapy.
- Medicine and Medical Research