Vasopressin Gene-Related Products in the Management of Breast Cancer
Annual rept. 1 Oct 96-30 Sep 97
DARTMOUTH COLL HANOVER NH
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The goal of this project is to improve the detection and treatment of breast cancer by characterizing vasopressin gene expression by this disease and determining the nature and role of products generated through this expression. We have now demonstrated that the vasopressin gene is expressed by seemingly all carcinoma in situ, and this new information added to an absence of vasopressin gene-related products from fibrocystic disease should provide us with a new screening test for distinguishing carcinoma in situ from atypical intraductal hyperplasia. Our recent studies on cell trafficking in breast cancer of vasopressin gene-products have shown that almost all protein processing is outside of conventional secretory vesicles, and components of glycopeptide-related cell surface antigen GRSA comprise both the 20 KDa and 40 KDa vasopressin-related proteins we have been characterizing. Therefore both of these proteins are potential targets for immunotherapy.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research