The Cloning of the BRCA1 Gene
Final rept. 1 Sep 94-31 Aug 97
MONTREAL GENERAL HOSPITAL (QUEBEC) RESEARCH INST
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The BRCA1 gene was cloned in 1994. Dr. Narod participated in this international effort. Dr. Narod has been active in characterizing the range and frequency of mutations in families with hereditary breast cancer, in Ashkenazi Jewish women with familial and sporadic breast and ovarian cancer, and in unselected Ontario women with ovarian cancer. By studying over 400 BRCA1 carriers identified through the course of these studies he has identified genetic and non-genetic risk modifiers and he has helped to evaluate the outcomes of genetic counselling of hereditary breast cancer patients. He has recently found that the use of oral contraceptives is protective against hereditary ovarian cancer and a history of moderate smoking is associated with a decreased risk of breast cancer in BRCA1 carriers.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research