Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl
Annual rept. 15 Aug 96-14 Aug 97
CALIFORNIA UNIV BERKELEY
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The purpose of this project was to identify genes responsible for inherited predisposition to breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others for a different reason and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowdens syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research