Environmental Exposures, Genetic Polymorphisms and p53 Mutational Spectra in a Case-Control Study of Breast Cancer.
Annual rept. 1 Jan 96-31 Dec 97
NATIONAL INSTITUTES OF HEALTH BETHESDA MD
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We had previously determined that the NAT2 slow acetylator genotype and cigarette smoking is a risk factor for postmenopausal Caucasian women. This year, diet and meat consumption was not found to be a risk factor for breast cancer. Analysis for NAT1 did not reveal additional risks. Other genetic analyses are completed for MEH3, MEH4, CYP2D6, SOD, GSTM1, GST-T and CYP1A1. CYP1A1 data have been studied in relation to PCB exposure, and a modest risk has been found in women with the highest PCB body burdens. Currently, 215 blocks have been received for p53 analysis, 93 have been immunohistochemical stained, and SSCP is in progress. To corroborate the epidemiological data, 38 breast cell strains have been established and metabolism is being studied in relation to genotypes. Methodological conditions are being addressed. Finally, to identify smoking-related risk, we have been studying smoking behavior and addiction, where, genetic polymorphisms in dopamine receptors have been associated with depression and smoking but tyrosine hydrolase, serotonin transporters, and dopamine D3 receptors are not. In 1997, 5 papers have been published, 10 have been accepted and 3 have been submitted.
- *CASE STUDIES
- *BREAST CANCER
- CARGO VEHICLES
- RECEPTOR SITES(PHYSIOLOGY)
- DRUG ADDICTION
- BIOLOGICAL STAINS
- TOBACCO SMOKING
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Polymer Chemistry