Accession Number:

ADA346680

Title:

Molecular Diagnosis for Breast Malignancy

Descriptive Note:

Annual rept. 1 Jul 96-30 Jun 97

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1997-07-01

Pagination or Media Count:

19.0

Abstract:

This grant investigates the role of EMMPRIN, seprase and DPPW in breast cancer invasion and metastasis. The aims are to evaluate these conceivable invasion-related molecules as prognostic markers for node-negative breast cancer. We identified, cloned and expressed a full-length cDNA that encoded for a human tumor derived collagenase-stimulating factor, called EMMPRIN. Vectors containing EMMPRIN sense and antisense inserts have been constructed and expression studies showed that EMMPRIN is expressed at invadopodia of invasive breast carcinoma cells where it interacts with membrane proteases and integrins.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE