Arachidonate Metabolism in Breast Cancer Cultures: Identification of Antagonist/Agonist for Possible Intervention Strategies.
Annual rept. 1 Oct 96-30 Sep 97,
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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There has been increasing evidence that high intake of dietary fats and obesity, in general, correlate with increased risk of breast cancer. The breast, as an apocrine gland shrouded in fat pads, may Possess special regulatory mechanisms to protect the epithelial cells from stimulation by products generated in the rich mileu of the surroundings. Our hypothesis addresses that issue suggesting that loss of protective regulatory mechanisms in breast tissue leaves breast epithelial cells vulnerable to unregulated stimulation. Our studies have addressed regulatory mechanisms in production of bioactive lipids in breast cancer cells. We have shown, using estrogen receptor - breast cancer cell lines, expression of various lipoxygenase LO and cyclooxygenase mRNA espression. Insulin-like growth factor-I and transferrin each stimulated production of 5-LO products in 4 different breast cancer cell lines.
- Medicine and Medical Research