Accession Number:

ADA346618

Title:

The Role of Protein Kinase-C in Breast Cancer Invasion and Metastasis

Descriptive Note:

Annual rept. 1 Sep 96-31 Aug 97

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

67.0

Abstract:

In a study of the effects of treatment with the anti-P.C. acting drug Bryostatin-1, the levels of protein kinase C isoforms in patient peripheral blood lymphocytes was studied. While the levels of many of the isoforms was quite variable, protein kinase C eta was frequently elevated shortly after the start of treatment and then subsequently suppressed during long-term exposure to the agent. The level of MMP-9 in the plasma of these patients was highly variable and no active enzyme was detected. Studies are under way to determine if this variation is seen in subjects that are cancer free. We have generated preliminary data that suggest that PARP cleavage, Bcl-2 protein levels and Raf and MAPK phosphorylation state may be useful markers of Bryostatin action.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE