Accession Number:

ADA346554

Title:

Modulation of Molecular Markers by CLA

Descriptive Note:

Annual rept. 14 Sep 96-13 Sep 97

Corporate Author:

AMC CANCER RESEARCH CENTER DENVER CO

Personal Author(s):

• Thompson, Henry J.

Report Date:

1997-10-01

Pagination or Media Count:

52.0

Abstract:

Conjugated linoleic acid CLA is a naturally occurring component of the food supply that inhibits mammary carcinogenesis. Data obtained on this project indicate 1 that the anticancer activity of CLA is unlikely to be explained based soley on its antioxidant activity 2 that CLA is unlikely to inhibit carcinogenesis by directly antagonizing linoleic acid metabolism 3 that CLA inhibits carcinogenesis irrespective of the presence or absence of the codon 61 mutation in the Ha-ras gene. Candidate genes that are over-expressed specifically in mammary carcinomas have been identified. The effects of CLA on the expression of these genes will be investigated to determined if they are involved in the inhibition of mammary carcinogenesis by CLA.

Descriptors:

• *MARKERS
• *MAMMARY GLANDS
• *LINOLEIC ACID
• *BREAST CANCER
• *ONCOGENESIS
• MOLECULES
• METABOLISM
• GENES
• SUPPLIES
• INHIBITION
• MODULATION
• FOOD
• ANTIOXIDANTS

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE