Accession Number:

ADA346541

Title:

Pleiotrophin as a Growth Factor and Therapeutic Target in Breast Cancer

Descriptive Note:

Annual rept. 15 Sep 96-14 Sep 97

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

75.0

Abstract:

Two major findings with respect to the role and regulation of the growth factor pleiotrophin PTN were contributed by my laboratory 1 We expanded our discovery that in the human PTN gene a tissue-specific promoter was generated by the germ line insertion of an endogenous retrovirus 25 million years ago. This is the first report of a retroviral insertion contributing a tissue-specific promoter in a human gene and only the second human gene that was reported to be altered in its expression pattern by retroviral elements. We now report that this element is also inserted in the BRCA-1 locus. 2 In addition, we analyzed the signal transduction pattern of PTN and showed that it works through MAP kinase PI 3-kinase. Two proteins close to 200 kDa are phosphorylated in response to PTN and are likely candidate receptors for this growth factor.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE