Cytokines, Neovascularization and Breast Cancer
Annual rept. 1 Oct 96-30 Sep 97
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
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Angiogenesis is critical for breast cancer growth and metastasis. Although several angiogenic factors AF such as Interleukin 8 IL-8 have been described, little is known about the regulation of this process. In many ways, cancers behave like abnormally healing wounds. Both are characterized by infiltration with inflammatory cells, fibrosis and angiogenesis. We hypothesize that tumors stimulate their own growth and metastases by the local production of angiogenic factors. Further, this production of angiogenic factors is regulated by pleuripotent cytokines, much like in healing wounds. In order to prove this hypothesis, we examined human breast cancers for the presence of known angiogenic factors and their receptors. This work demonstrated that IL-8 and its receptors are found in human breast cancer. In a second study, we examined the ability of breast cancer cells in vitro to produce IL-8 in non stimulated, and stimulated conditions.
- Anatomy and Physiology
- Medicine and Medical Research