Accession Number:

ADA343280

Title:

Preclinical Toxicology Studies for New Drugs and Vaccines.

Descriptive Note:

Final rept. 15 Nov 91-15 Apr 98,

Corporate Author:

ILLINOIS UNIV AT CHICAGO CIRCLE

Personal Author(s):

• Levine, Barry D.

Report Date:

1998-05-01

Pagination or Media Count:

33.0

Abstract:

This project evaluated the toxicity and safety of several drugs under development. During the contract, tasks conducted included mutagenicity tests developmental toxicity studies in rats and rabbits acute toxicity studies in rats and mice two, four and thirteen week toxicity studies in rats and dogs a six month toxicity study in rats fertilitylearly embryonic development studies, in rats a perinatal toxicity study in rats and a one year toxicity study in dogs. Drugs studied included WR242S ii Tartrate, WR2386OS Succinate, Halofantrine HCl, Pyridostigmine Bromide, WR6O26 Dihydrochioride, H1-6 Dichloride, WR26941O, Atropine, WR279396, and Ampicillin.

Descriptors:

• *CLINICAL MEDICINE
• *CASE STUDIES
• *VACCINES
• *TOXICOLOGY
• RATS
• MICE
• PYRIDOSTIGMINE BROMIDE
• DOGS
• PENICILLINS
• ATROPINE
• LABORATORY ANIMALS

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE