Study of the Met Tyrosine Kinase in the Pathogenesis of Breast Cancer.
Annual rept. 23 Sep 96-22 Sep 97,
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Pagination or Media Count:
Breast cancer is the most common malignancy affecting women in the Western World. Epidemiological studies have defined certain factors that may contribute to the risk of breast cancer, the most important one being a family history of the disease 1, 2. Approximately 5-10 of breast cancers are associated with inherited susceptibility with one or more autosomal dominant traits. Linkage at the estrogen receptor on chromosome 6 has also been reported in breast cancer family with a late-onset mode 3. Families with germ-line p53 mutations Li-Fraumeni Syndrome often have multiple breast cancers, representing only about 1 of all familial breast cancer cases 4. Molecular analysis of sporadic breast cancer DNAs has revealed loss of heterozygosity on chromosomes 1p, 1q, 3p, 6q, 7q, 8q, lip, 13q, 15q, 16q, 17p, 17q, and 18q 5. Gene amplification is also frequently observed in the c- myc, HER2neu, and int-2PRAD-1 genes of breast tumors 6-8. Furthermore, a significant association between the level of nm23 expression and aggressive tumor behavior has been demonstrated.
- Medicine and Medical Research