Interphase Cytogenetics in Breast Tumors P53 Gene Alterations
Midterm rept. 27 Oct 92-30 Sep 93
ARMED FORCES INST OF PATHOLOGY WASHINGTON DC
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HE PURPOSE OF THIS RESEARCH IS TO COMPARE NUMERICAL CHROMOSOME ABERRATIONS AND P53 GENE ALTERATIONS IN 250 NODE-NEGATIVE BREAST CANCERS TO 250 NON-POSITIVE BREAST CANCERS AND THEIR SURVIVAL. SCOPE Interphase cytogenetics will be performed in paraffin sections utilizing biotinylated probes specific for centromeric regions of chromosomes 1, 8, 11, 13, 17, 18, and X. Chromosome profiles based on 300 tumor cells will be generated for each patient.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research