Role of the Mammary Adenocarcinoma Cell Transferrin Response in Breast Cancer Metastasis
Annual rept. 22 Aug 96-21 Aug 97
M D ANDERSON CANCER CENTER HOUSTON TX
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Breast cancer cell growth response to transferrin Tf and expression of the transferrin receptor TfR were found to correlate with metastatic capability. To test this observation, Tf responsiveness or TfR expression were increased in selected poorly-metastatic breast cancer lines, through means of selection and transfection processes. This resulted in increased metastatic behavior in certain low metastatic rat breast cancer cell types. Studies into the differences in Tf-induced intracellular responses by the altered and parental lines have been initiated. For further experiments of this nature, additional plasmid constructs containing the human TfR cDNA in sense and anti-sense orientation were developed.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research