Accession Number:

ADA341369

Title:

Control of Cell Morphology: Signaling by the Receptor Notch

Descriptive Note:

Annual rept. 1 Oct 96-30 Sep 97

Corporate Author:

FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

18.0

Abstract:

The goal of our study is to identify the signaling pathway by which the Drosophila gene Notch controls cell morphology, and to distinguish it from the pathway by which Notch controls cell identity. The specific third year goals of the project were I to investigate biochemically the interaction between NOTCH protein and the axonal signaling protein DISABLED and 2 to further characterize the genetic interaction between Notch and abl mutations as a prelude to performing a genetic screen for new elements of the Notchabl pathway.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE