Accession Number:

ADA339371

Title:

Neural Responses to Injury: Prevention, Protection and Repair; Volume 4: Neurochemical Protection of the Brain, Neural Plasticity and Repair.

Descriptive Note:

Annual rept. 20 Sep 95-19 Sep 96,

Corporate Author:

LOUISIANA STATE UNIV NEW ORLEANS

Personal Author(s):

Report Date:

1996-10-01

Pagination or Media Count:

171.0

Abstract:

The experimental animals used during this period for the project, Neural Responses to Injury Prevention, Protection, and Repair, Subproject Neurochemical Protection of the Brain, Neural Plasticity and Repair, are as follows Species Number Allowed Number Used LSU IACUC Rat sprague-Dawle 125 125 1046 Rat Sprague-Dawle 91 91 1045 The development of chronic epilepsy is a very serious complication of head injury, neurodegenerative diseases, brain tumors, and exposure to neurotoxic agents. Head injury is often associated with loss of short-term memory, indicating trauma to the hippocampal formation, the brain region most commonly associated with epileptic brain damage. Underlying the formation of epilepsy epileptogenesis is proposed to be a vicious cycle initiated by the loss of neurons. In an attempt to repair andor replace lost synaptic connections, the brain can develop aberrant synaptic circuits that permit the propagation and amplification of waves of excitatory neurotransmission, eventually resulting in prolonged or repeated seizures status epilepticus. The massive amounts of excitatory amino acids released during these episodes can stimulate further neuronal loss excitotoxic damage, the formation of more aberrant synaptic circuits, and further seizures Choi and Rothinan, 1990. Excitotoxic damage has been demonstrated in several experimental models of status epilepticus Meldmm et al, 1973 Ben-Ari, 1995 Sloviter, 1987.

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE