Accession Number:

ADA339173

Title:

The Rap-1 Antloncogene in Breast Cancer

Descriptive Note:

Annual rept. 29 Aug 96-28 Aug 97

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

17.0

Abstract:

This project aims to devise strategies to antagonize the promitogenic action of Ras and thereby suppress the transforming activity of the Erb2 oncogene found in 70 of human breast adenocarcinomas. The initial strategy was based on the ability of the Rap-1 GTPase, when overexpressed to suppress the malignant phenotype of V12 Ras-transformed fibroblasts. It was anticipated that Rap-1 which shares an identical sequence corresponding to the primary Ras effector binding domain amino acids 32-44 when overexpressed, competes with Ras for initial mitogenic effectors. In the past year, we have continued to focus on the identification and characterization of proteins that interact with Rap-i and Ras through their effector loop in GTh-dependent fashion.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE