Accession Number:

ADA339114

Title:

Amplified Genes in Breast Cancer: Molecular Targets for Investigation and Therapy

Descriptive Note:

Annual rept. 1 Sep 96-31 Aug 97

Corporate Author:

SALK INST FOR BIOLOGICAL STUDIES LA JOLLA CA

Personal Author(s):

Report Date:

1997-08-01

Pagination or Media Count:

21.0

Abstract:

We showed that extrachromosomally amplified genes in double minute chromosomes DMs are removed from tumor cells through preferential incorporation into micronuclei that are generated in S-phase. This process is enhanced by DNA synthesis inhibitors, and requires p53 inactivation. In the past year, we developed technology that enables visualization of chromosome dynamics in living cells.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE