Amplified Genes in Breast Cancer: Molecular Targets for Investigation and Therapy
Annual rept. 1 Sep 96-31 Aug 97
SALK INST FOR BIOLOGICAL STUDIES LA JOLLA CA
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We showed that extrachromosomally amplified genes in double minute chromosomes DMs are removed from tumor cells through preferential incorporation into micronuclei that are generated in S-phase. This process is enhanced by DNA synthesis inhibitors, and requires p53 inactivation. In the past year, we developed technology that enables visualization of chromosome dynamics in living cells.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research