Accession Number:

ADA339071

Title:

Dry Fibrin Glue for the Repair of Severe Liver Injury in the Anesthetized Porcine Model.

Descriptive Note:

Final rept. 1 Mar 96-31 May 97,

Corporate Author:

WILLIAM BEAUMONT ARMY MEDICAL CENTER ELPASO TX

Personal Author(s):

Report Date:

1997-07-01

Pagination or Media Count:

15.0

Abstract:

Hemorrhage control is critical to survival of trauma patients. Unfortunately the methods available to stop bleeding have not changed in years pressure, tourniquets, gauze dressings, and sutures. This suggests that a substantial increase in survival can be effected by a simple and effective method of hemorrhage control. Dry Fibrin Sealant Dressings DFSD combine the benefits of liquid fibrin sealants with convenience of a ready to use dry powder dressing composed of pure human thrombin, fibrinogen, and calcium. The delivery of the DFSD is the same as any conventional gauze dressing, simply unwrap the dressing, place on the wound, and apply pressure for one to two minutes. A fibrin clot forms almost instantly that stops bleeding from small, medium and large vessels as well as large soft tissue wounds. We developed a liver injury model that replicates a gunshot wound to the central portion of the liver. In this potentially fatal liver injury model the DFSD instantly stopped bleeding when compared to a blinded control dressing p .05 and gauze packing p .05. The Dry Fibrin Sealant Dressing is simple, fast, lightweight, temperature independent and requires no special training. When fielded in its final form, we see this as a forward projection of advanced hemorrhage control, providing our casualties rapid, lifesaving and definitive control of bleeding.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE