Accession Number:

ADA339039

Title:

Breast Mucin Tumor-Specific Epitopes for Cancer Immunotherapy

Descriptive Note:

Annual rept. 1 Aug 96-31 Jul 97

Corporate Author:

TEXAS TECH UNIV AMARILLO

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

19.0

Abstract:

The objectives of the research program are to study the structure-immunogenicity relationships of a hypoglycosylated human tumor-specific mucin common to breast and other adenocarcinomas. Hypo-glycosylation of breast mucin leads to exposure of a tumor-specific epitope TSE. The structural and immunogenic properties of the TSE are being examined using synthetic mucin peptides and recombinant mucin proteins that contain the TSE andor mutations in potential glycosylation sites surrounding the TSE.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE