Breast Mucin Tumor-Specific Epitopes for Cancer Immunotherapy
Annual rept. 1 Aug 96-31 Jul 97
TEXAS TECH UNIV AMARILLO
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The objectives of the research program are to study the structure-immunogenicity relationships of a hypoglycosylated human tumor-specific mucin common to breast and other adenocarcinomas. Hypo-glycosylation of breast mucin leads to exposure of a tumor-specific epitope TSE. The structural and immunogenic properties of the TSE are being examined using synthetic mucin peptides and recombinant mucin proteins that contain the TSE andor mutations in potential glycosylation sites surrounding the TSE.
- Medicine and Medical Research