Accession Number:

ADA339025

Title:

Thermoregulatory, Endurance and Ultrastructural Effects of Acute and Subchronic Pyridostigmine Bromide Administration in the Exercising Rat.

Descriptive Note:

Technical rept.,

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1998-03-01

Pagination or Media Count:

25.0

Abstract:

Pyridostigmine PY is the drug currently approved for chemical agent prophylaxis. Previous studies have demonstrated that acute administration or high doses of PY have resulted in thermoregulatory, endurance and ultrastructural abnormalities. In this study the effects of acute APY, 100 ugkg, iv and subchronic PY for 2, 3, and 4 weeks PY2, PY3, PY4, 20 ughr, via osmotic pump administration on treadmill endurance when measured in rats to determine whether any voluntary muscle weakness occurs as a result of PY administration. APY rats had reduced endurance time 56 18 min mean SD vs 72 1 17 compared to saline controls and increased core temperatures at the start of exercise Tc, 38.9 o . 2oC vs 38.5 0. 6oC. These decrements were arneliorated with subchronic administration, and PY2 animals maintained lower Tc than SAL2 animals. Typical mitochondrial lesions detected with acute high doses of PY lmgkg were not observed in any of these specimens. Decrements in endurance and thermoregulation and ultrastructural abnormalities previously seen with acute PY are not evident after subchronic administration for up to 4 weeks.

Subject Categories:

  • Biochemistry
  • Stress Physiology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE