Accession Number:

ADA336351

Title:

Estimation of Human Toxicity From Animal Inhalation Toxicity Data: 1. Minute Volume-Body Weight Relationships Between Animals And Man.

Descriptive Note:

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

50.0

Abstract:

The relationship between body weight BW and respiratory minute volume Vm was reviewed by collecting a data base from the literature of minute volume rates that encompassed species from mice at 12 g body weight to horses and a giraffe at 500 kg body weight. The data were separated into anesthetized and non-anesthetized groups and juvenile animals were removed from the non-anesthetized group. The final data set of non-anesthetized animals contained 131 studies representing 2125 animals and 18 species. The data show a power-law allometric relationship between the minute volume and body weight. The scaling or allometric parameters in this power-law have been estimated using a linear regression of the logarithms of the minute volume against body weight. The resulting allometric equations were Log10Vm -0.286 0.802 Log10BW or Vm 0.518 BW0.802. From these equations a corresponding set of minute volumes were obtained for various body weights of humans eg. 15.6 Lmin for a 70 kg human. The results of the analyses were compared to similar studies in the literature. The relationship is recommended for military uses because it is derived from non-anesthetized, young adult mammals which are expected to mimic the soldier.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE