Pathogenesis of Septic Acute Lung Injury and Strategies for Immuno-Pharmacological Therapy.
Final rept. 1 May 93-31 Jul 96
VIRGINIA COMMONWEALTH UNIV RICHMOND
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During the period of the past two years, this laboratory has focused on the phenomenon of acute lung injury following the onset of systemic infection. To accomplish this we have used the pig to model acute lung injury. In our laboratory using the model as we have developed it, the pig predictably develops acute lung injury following an intravenous infusion of a predetermined quantity of live Pseudomonas aeruginosa. Over the last eight years the model has undergone progressive refinements in the quest for more accurately mimicking bacterial sepsis and subsequent lung injury as it occurs in humans. This research funded by the DAMD has led us to progressively greater degrees of sophistication of our understanding of the acute inflammatory responses which lead to acute lung injury following onset of severe systemic bacterial infection. Included in this midterm report are the results of research performed during the past two years of DAMD sponsorship.
- Anatomy and Physiology