TGFa-myc Interactions in Mammary Tumorigenesis.
Annual rept. 1 Sep 96-31 Aug 97,
GEORGETOWN UNIV WASHINGTON DC
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This grant continues to study the nature of the synergistic interaction of the growth factor TGF alpha and the nuclear protooncogene product c-myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a mutifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, and suppression of cell death apoptosis. In addition, we observed that the TGF alpha-related growth factor amphiregulin was likely to have tumor promoting effects similar toTGF alpha in breast cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research