Accession Number:

ADA334931

Title:

TGFa-myc Interactions in Mammary Tumorigenesis.

Descriptive Note:

Annual rept. 1 Sep 96-31 Aug 97,

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

68.0

Abstract:

This grant continues to study the nature of the synergistic interaction of the growth factor TGF alpha and the nuclear protooncogene product c-myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a mutifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, and suppression of cell death apoptosis. In addition, we observed that the TGF alpha-related growth factor amphiregulin was likely to have tumor promoting effects similar toTGF alpha in breast cancer.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE