Induction of Immunity to a Breast Cancer Associated Mucin in Transgenic Mice Expressing the Human Antigen - A Preclinical Study.
Annual rept. 1 Sep 96-31 Aug 97,
ILLINOIS UNIV AT CHICAGO CIRCLE
Pagination or Media Count:
Polymorphic epithelial mucin PEM, a product of the MUC1 gene, is aberrantly ex- pressed by human breast cancer cells. It is a potential target for immune-mediated attack. The induction of immunity to breast cancer associated mucin could have important implications for the treatment of patients with breast cancer. Two approach 5 are being evaluated to augment the immunity to PEM. The studies are being carried out in transgenic mice that express human mucin as self, mimicking as closely as possible the disease in humans. The first involves the introduction and expression of cytokine genes into mouse breast cancer cells modified to express human breast cancer associated mucin. The second involves the introduction and expression of genes specifying co stimulatory molecules required for T cell activation into the modified cells. Significant progress toward the accomplishment of these goals was
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research