Accession Number:

ADA334915

Title:

A Novel Tyrosine Kinase Expressed in Breast Tumors

Descriptive Note:

Annual rept 19 Aug 96-18 Aug 97

Corporate Author:

ILLINOIS UNIV AT CHICAGO CIRCLE

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

15.0

Abstract:

Tyrosine kinases mediate cellular responses to environmental conditions, and they are involved in regulation of proliferation and cell differentiation in a variety of systems. Overexpression or mutation of tyrosine kinases has been shown to result in cellular transformation, and this has been seen in breast tumors. Our laboratory identified a novel mouse epithelial cell specific intracellular tyrosine kinase, which we named Sik, for Src-related intestinal kinase. We isolated the human homologue of Sik and determined that it is identical to a novel tyrosine kinase termed Brk Breast tumor kinase. Brk was

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE