Accession Number:

ADA334912

Title:

Development of PEA3 as a Potential Gene Therapy Agent for Breast Cancer

Descriptive Note:

Annual rept 1 Sep 96-31 Aug 97

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

28.0

Abstract:

13. ABSTRACT Maximum 200 The HER-2neu gene is frequently amplified and or its protein product, p185, is frequently overexpressed in a number of human cancers. Overexpression of p185 correlates with poor prognosis and low survival rates in breast and ovarian cancer patients. Downregulation of HER-2neu gene is a way to reverse the transformation phenotype induced by HER-2neu. In this project, the effects of PEA3, a member of ets oncogene family of transcriptional regulatory factors, on HER-2neu expression were investigated to learn whether PEA3 plays a role in HER-2neu induced transformation and could be developed to a gene therapeutic agent. This progress report includes our recent data which demonstrating that, PEA3 is indeed a trans-repressor of HER-2neu promoter in HER-2neu overexpressing human cancer cells.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE